7E8Z
Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with SS81
Summary for 7E8Z
Entry DOI | 10.2210/pdb7e8z/pdb |
Related | 4QHO |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, ... (4 entities in total) |
Functional Keywords | double-stranded beta helix, 2og and fe(ii)-dependent oxygenase, rna demethylase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57220.72 |
Authors | Tam, N.Y.,Ng, Y.M.,Shishodia, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (deposition date: 2021-03-03, release date: 2021-10-13, Last modification date: 2023-11-29) |
Primary citation | Shishodia, S.,Demetriades, M.,Zhang, D.,Tam, N.Y.,Maheswaran, P.,Clunie-O'Connor, C.,Tumber, A.,Leung, I.K.H.,Ng, Y.M.,Leissing, T.M.,El-Sagheer, A.H.,Salah, E.,Brown, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J. Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. J.Med.Chem., 64:16609-16625, 2021 Cited by PubMed: 34762429DOI: 10.1021/acs.jmedchem.1c01204 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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