7E8Z

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with SS81

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Alpha-ketoglutarate-dependent dioxygenase FTO	polymer	495	56823.0	1	UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934) In PDB	Homo sapiens (Human)	Fat mass and obesity-associated protein,U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO,U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO,mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO,m6A(m)-demethylase FTO,mRNA N(6)-methyladenosine demethylase FTO,tRNA N1-methyl adenine demethylase FTO
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid	non-polymer		332.3	1	Chemie (HZX)
4		water	water		18.0	12	Chemie (HOH)

Sequence modifications

A: 32 - 505 (UniProt: Q9C0B1)

PDB	External Database	Details
Met 11	-	initiating methionine
Gly 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ser 22	-	expression tag
Gly 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Pro 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
Met 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56823.0
Non-Polymers*	Number of molecules	2
	Total formula weight	397.7
All*	Total formula weight	57220.7

*Water molecules are not included.