7E8Z

Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with SS81

Summary for 7E8Z

• Entry DOI: 10.2210/pdb7e8z/pdb
• Related: 4QHO
• Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, ... (4 entities in total)
• Functional Keywords: double-stranded beta helix, 2og and fe(ii)-dependent oxygenase, rna demethylase, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 57220.72

Authors

Tam, N.Y.,Ng, Y.M.,Shishodia, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (deposition date: 2021-03-03, release date: 2021-10-13, Last modification date: 2023-11-29)

• Primary citation: Shishodia, S.,Demetriades, M.,Zhang, D.,Tam, N.Y.,Maheswaran, P.,Clunie-O'Connor, C.,Tumber, A.,Leung, I.K.H.,Ng, Y.M.,Leissing, T.M.,El-Sagheer, A.H.,Salah, E.,Brown, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J.; Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.; J.Med.Chem., 64:16609-16625, 2021; PubMed: 34762429; DOI: 10.1021/acs.jmedchem.1c01204

Experimental method

X-RAY DIFFRACTION (2.55 Å)