7E7F
Human CYP11B1 mutant in complex with metyrapone
Summary for 7E7F
| Entry DOI | 10.2210/pdb7e7f/pdb |
| Descriptor | Cytochrome P450 11B1, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, METYRAPONE, ... (6 entities in total) |
| Functional Keywords | p450, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 57665.43 |
| Authors | Mukai, K.,Sugimoto, H.,Reiko, S.,Matsuura, T.,Hishiki, T.,Kagawa, N. (deposition date: 2021-02-26, release date: 2022-01-05, Last modification date: 2023-11-29) |
| Primary citation | Mukai, K.,Sugimoto, H.,Kamiya, K.,Suzuki, R.,Matsuura, T.,Hishiki, T.,Shimada, H.,Shiro, Y.,Suematsu, M.,Kagawa, N. Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. Curr Res Struct Biol, 3:192-205, 2021 Cited by PubMed: 34485929DOI: 10.1016/j.crstbi.2021.08.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report
