Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7E7F

Human CYP11B1 mutant in complex with metyrapone

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0004507molecular_functionsteroid 11-beta-monooxygenase activity
A0005506molecular_functioniron ion binding
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0006629biological_processlipid metabolic process
A0006694biological_processsteroid biosynthetic process
A0006700biological_processC21-steroid hormone biosynthetic process
A0006704biological_processglucocorticoid biosynthetic process
A0006955biological_processimmune response
A0008203biological_processcholesterol metabolic process
A0008217biological_processregulation of blood pressure
A0016125biological_processsterol metabolic process
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0032342biological_processaldosterone biosynthetic process
A0032870biological_processcellular response to hormone stimulus
A0034650biological_processcortisol metabolic process
A0034651biological_processcortisol biosynthetic process
A0035865biological_processcellular response to potassium ion
A0042593biological_processglucose homeostasis
A0046872molecular_functionmetal ion binding
A0047783molecular_functioncorticosterone 18-monooxygenase activity
A0071375biological_processcellular response to peptide hormone stimulus
A1901615biological_processorganic hydroxy compound metabolic process
Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGMRQCLG
ChainResidueDetails
APHE443-GLY452

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:P19099
ChainResidueDetails
ACYS450

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon