7DL2
Cryo-EM structure of human TSC complex
Summary for 7DL2
Entry DOI | 10.2210/pdb7dl2/pdb |
EMDB information | 30708 30709 30710 30711 |
Descriptor | Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... (4 entities in total) |
Functional Keywords | tsc complex, regulator of cell growth, gtpase-activating protein, elongated arch-shaped fold, gene regulation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 689396.78 |
Authors | |
Primary citation | Yang, H.,Yu, Z.,Chen, X.,Li, J.,Li, N.,Cheng, J.,Gao, N.,Yuan, H.X.,Ye, D.,Guan, K.L.,Xu, Y. Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun, 12:339-339, 2021 Cited by PubMed: 33436626DOI: 10.1038/s41467-020-20522-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.4 Å) |
Structure validation
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