7CTH

Cryo-EM structure of dengue virus serotype 2 in complex with the scFv fragment of the broadly neutralizing antibody EDE1 C10

7CTH の概要

• エントリーDOI: 10.2210/pdb7cth/pdb
• EMDBエントリー: 30465
• 分子名称: Core protein, Single Chain Variable Fragment, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: dengue virus, antibody, broadly neutralizing, flavivirus, virus
• 由来する生物種: Dengue virus 2; 詳細
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 251601.36

構造登録者

Zhang, X.,Sharma, A.,Duquerroy, S.,Zhou, Z.H.,Rey, F.A. (登録日: 2020-08-19, 公開日: 2021-12-01, 最終更新日: 2022-02-16)

• 主引用文献: Sharma, A.,Zhang, X.,Dejnirattisai, W.,Dai, X.,Gong, D.,Wongwiwat, W.,Duquerroy, S.,Rouvinski, A.,Vaney, M.C.,Guardado-Calvo, P.,Haouz, A.,England, P.,Sun, R.,Zhou, Z.H.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A.; The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses.; Cell, 184:6052-, 2021; PubMed: 34852239; DOI: 10.1016/j.cell.2021.11.010

実験手法

ELECTRON MICROSCOPY (3.5 Å)