7CMZ
Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8
Summary for 7CMZ
Entry DOI | 10.2210/pdb7cmz/pdb |
Descriptor | DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | topbp1, protein binding-hydrolase complex, protein binding/hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28544.43 |
Authors | |
Primary citation | Ma, S.,Cao, C.,Che, S.,Wang, Y.,Su, D.,Liu, S.,Gong, W.,Liu, L.,Sun, J.,Zhao, J.,Wang, Q.,Song, N.,Ge, T.,Guo, Q.,Tian, S.,Chen, C.D.,Zhang, T.,Wang, J.,Ding, X.,Yang, F.,Ying, G.,Yang, J.,Zhang, K.,Zhu, Y.,Yao, Z.,Yang, N.,Shi, L. PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability. Sci Adv, 7:-, 2021 Cited by PubMed: 33952527DOI: 10.1126/sciadv.abf7684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.695 Å) |
Structure validation
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