7CMS

Crystal structure of Tryptophanyl-tRNA synthetase from Bacillus stearothermophilus in complex with chuangxinmycin

Summary for 7CMS

• Entry DOI: 10.2210/pdb7cms/pdb
• Descriptor: Tryptophan--tRNA ligase, (5~{S},6~{R})-5-methyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: chuangxinmycin, antibiotic
• Biological source: Geobacillus stearothermophilus
• Total number of polymer chains: 2
• Total formula weight: 75107.86

Authors

Lyu, G.,Fan, S.,Jin, Y.,Zou, S.,Wu, G.,Yang, Z. (deposition date: 2020-07-28, release date: 2021-08-04, Last modification date: 2023-11-29)

• Primary citation: Fan, S.,Lv, G.,Feng, X.,Wu, G.,Jin, Y.,Yan, M.,Yang, Z.; Structural insights into the specific interaction between Geobacillus stearothermophilus tryptophanyl-tRNA synthetase and antimicrobial Chuangxinmycin.; J.Biol.Chem., 298:101580-, 2022; DOI: 10.1016/j.jbc.2022.101580

Experimental method

X-RAY DIFFRACTION (2.2 Å)