7CMS
Crystal structure of Tryptophanyl-tRNA synthetase from Bacillus stearothermophilus in complex with chuangxinmycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 9E0 A 401 |
| Chain | Residue |
| A | PHE5 |
| A | HOH505 |
| A | GLY7 |
| A | VAL40 |
| A | HIS43 |
| A | TYR125 |
| A | ASP132 |
| A | ILE133 |
| A | VAL141 |
| A | GLN147 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | LYS192 |
| A | SER194 |
| A | LYS195 |
| A | HOH514 |
| A | HOH520 |
| A | HOH617 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue 9E0 B 401 |
| Chain | Residue |
| B | PHE5 |
| B | GLY7 |
| B | HIS43 |
| B | MET129 |
| B | ASP132 |
| B | GLN147 |
| B | LYS195 |
| B | HOH526 |
| B | HOH602 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | LYS192 |
| B | SER194 |
| B | LYS195 |
| B | HOH529 |
| B | HOH530 |
| B | HOH605 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 10 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..SGvITIGNY |
| Chain | Residue | Details |
| A | PRO10-TYR19 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Motif: {"description":"'HIGH' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"'KMSKS' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26555258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DK4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 481 |
| Chain | Residue | Details |
| A | LYS111 | electrostatic stabiliser |
| A | LYS192 | electrostatic stabiliser |
| A | LYS195 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 481 |
| Chain | Residue | Details |
| B | LYS111 | electrostatic stabiliser |
| B | LYS192 | electrostatic stabiliser |
| B | LYS195 | electrostatic stabiliser |
