7CLZ

Crystal structure of Alp1U W187F/Y247F in complex with fluostatin C

Summary for 7CLZ

• Entry DOI: 10.2210/pdb7clz/pdb
• Related: 6KXH
• Descriptor: Putative hydrolase, Fluostatin C, SODIUM ION, ... (6 entities in total)
• Functional Keywords: substrate, complex, biosynthesis, hydrolase
• Biological source: Streptomyces ambofaciens (strain ATCC 23877 / 3486 / DSM 40053 / JCM 4204 / NBRC 12836 / NRRL B-2516)
• Total number of polymer chains: 4
• Total formula weight: 149662.36

Authors

Zhang, L.,De, B.C. (deposition date: 2020-07-22, release date: 2020-10-07, Last modification date: 2023-11-29)

• Primary citation: Zhang, L.,De, B.C.,Zhang, W.,Mandi, A.,Fang, Z.,Yang, C.,Zhu, Y.,Kurtan, T.,Zhang, C.; Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha / beta-fold epoxide hydrolase Alp1U.; J.Biol.Chem., 295:16987-16997, 2020; PubMed: 33004437; DOI: 10.1074/jbc.RA120.015563

Experimental method

X-RAY DIFFRACTION (2.10001009432 Å)