7CFO

Crystal structure of human RXRalpha ligand binding domain complexed with CBTF-EE.

Summary for 7CFO

Entry DOI	10.2210/pdb7cfo/pdb
Descriptor	Retinoic acid receptor RXR-alpha, 1-[3-(2-ethoxyethoxy)-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl]-2-(trifluoromethyl)benzimidazole-5-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	retinoid x receptor alpha, antagonist, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	110194.98
Authors	Watanabe, M.,Fujihara, M.,Motoyama, T.,Kawasaki, M.,Yamada, S.,Takamura, Y.,Ito, S.,Makishima, M.,Nakano, S.,Kakuta, H. (deposition date: 2020-06-27, release date: 2021-01-06, Last modification date: 2023-11-29)
Primary citation	Watanabe, M.,Fujihara, M.,Motoyama, T.,Kawasaki, M.,Yamada, S.,Takamura, Y.,Ito, S.,Makishima, M.,Nakano, S.,Kakuta, H. Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers. J.Med.Chem., 64:430-439, 2021 Cited by PubMed: 33356247 DOI: 10.1021/acs.jmedchem.0c01354 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation