7CCA

Crystal structure of White Spot Syndrome Virus Thymidylate Synthase - ternary complex with Methotrexate and dUMP

Summary for 7CCA

• Entry DOI: 10.2210/pdb7cca/pdb
• Related: 7CC8
• Descriptor: Thymidylate Synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, ... (4 entities in total)
• Functional Keywords: thymidylate synthase, biosynthetic protein, transferase
• Biological source: White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV)
• Total number of polymer chains: 2
• Total formula weight: 69911.91

Authors

Panchal, N.V.,Kumar, S.,Shaikh, N.,Vasudevan, D. (deposition date: 2020-06-16, release date: 2020-11-25, Last modification date: 2023-11-29)

• Primary citation: Panchal, V.,Kumar, S.,Hossain, S.N.,Vasudevan, D.; Structure analysis of thymidylate synthase from white spot syndrome virus reveals WSSV-specific structural elements.; Int.J.Biol.Macromol., 167:1168-1175, 2021; PubMed: 33197475; DOI: 10.1016/j.ijbiomac.2020.11.071

Experimental method

X-RAY DIFFRACTION (2.75 Å)