7CCA
Crystal structure of White Spot Syndrome Virus Thymidylate Synthase - ternary complex with Methotrexate and dUMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Thymidylate Synthase | polymer | 297 | 34193.3 | 2 | UniProt (Q77J90) Pfam (PF00303) | White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) | Wsv067 |
| 2 | C, E (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
| 3 | D, F (A, B) | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 289 (UniProt: Q77J90)
| PDB | External Database | Details |
|---|---|---|
| Leu 290 | - | expression tag |
| Glu 291 | - | expression tag |
| His 292 | - | expression tag |
| His 293 | - | expression tag |
| His 294 | - | expression tag |
| His 295 | - | expression tag |
| His 296 | - | expression tag |
| His 297 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68386.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1525.2 | |
| All* | Total formula weight | 69911.9 |
