7CCA
Crystal structure of White Spot Syndrome Virus Thymidylate Synthase - ternary complex with Methotrexate and dUMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue UMP A 301 |
| Chain | Residue |
| A | ARG24 |
| A | TYR233 |
| A | MTX302 |
| B | ARG150 |
| B | ARG151 |
| A | CYS170 |
| A | HIS171 |
| A | GLN189 |
| A | ARG190 |
| A | SER191 |
| A | ASP193 |
| A | ASN201 |
| A | HIS231 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue MTX A 302 |
| Chain | Residue |
| A | HIS82 |
| A | ILE83 |
| A | ASP193 |
| A | GLY197 |
| A | PHE200 |
| A | TYR233 |
| A | LYS286 |
| A | UMP301 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue UMP B 301 |
| Chain | Residue |
| A | ARG150 |
| A | ARG151 |
| B | ARG24 |
| B | CYS170 |
| B | HIS171 |
| B | GLN189 |
| B | ARG190 |
| B | SER191 |
| B | GLY192 |
| B | ASP193 |
| B | ASN201 |
| B | HIS231 |
| B | TYR233 |
| B | MTX302 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue MTX B 302 |
| Chain | Residue |
| B | PHE55 |
| B | ILE81 |
| B | HIS82 |
| B | ILE83 |
| B | LEU167 |
| B | ASP193 |
| B | GLY197 |
| B | PHE200 |
| B | TYR233 |
| B | LYS286 |
| B | UMP301 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrmImtaWNpmdlhlma.....LpPCHmtaQFyV |
| Chain | Residue | Details |
| A | ARG150-VAL178 |
