7C5E
Crystal structure of Keap1 in complex with fumarate (FUM)
Summary for 7C5E
| Entry DOI | 10.2210/pdb7c5e/pdb |
| Related | 6LRZ |
| Descriptor | Kelch-like ECH-associated protein 1, FUMARIC ACID, ACETATE ION, ... (6 entities in total) |
| Functional Keywords | beta-propeller domain, oxidative stress, keap1-nrf2 system, dmf, inhibitor complex, cytosolic protein |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 35284.11 |
| Authors | Padmanabhan, B.,Unni, S.,Deshmukh, P. (deposition date: 2020-05-19, release date: 2020-08-05, Last modification date: 2023-11-29) |
| Primary citation | Unni, S.,Deshmukh, P.,Krishnappa, G.,Kommu, P.,Padmanabhan, B. Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1. Febs J., 288:1599-1613, 2021 Cited by PubMed: 32672401DOI: 10.1111/febs.15485 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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