7BVF
Cryo-EM structure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Summary for 7BVF
Entry DOI | 10.2210/pdb7bvf/pdb |
EMDB information | 30218 |
Descriptor | Probable arabinosyltransferase B, Probable arabinosyltransferase A, Meromycolate extension acyl carrier protein, ... (7 entities in total) |
Functional Keywords | mycobacterium tuberculosis, cell wall synthesis, drug target, ethambutol, arabinosyltransferase, emba, embb, embc, acyl carrier protein, arabinogalactan, lipoarabinomannan, drug resistance, transferase |
Biological source | Mycobacterium tuberculosis H37Rv More |
Total number of polymer chains | 3 |
Total formula weight | 251817.41 |
Authors | |
Primary citation | Zhang, L.,Zhao, Y.,Gao, Y.,Wu, L.,Gao, R.,Zhang, Q.,Wang, Y.,Wu, C.,Wu, F.,Gurcha, S.S.,Veerapen, N.,Batt, S.M.,Zhao, W.,Qin, L.,Yang, X.,Wang, M.,Zhu, Y.,Zhang, B.,Bi, L.,Zhang, X.,Yang, H.,Guddat, L.W.,Xu, W.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z. Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Science, 368:1211-1219, 2020 Cited by PubMed: 32327601DOI: 10.1126/science.aba9102 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.97 Å) |
Structure validation
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