7BBG

CRYSTAL STRUCTURE OF HLA-A2-WT1-RMF AND FAB 11D06

Summary for 7BBG

• Entry DOI: 10.2210/pdb7bbg/pdb
• Descriptor: MHC class I antigen, Beta-2-microglobulin, Wilms tumor 1 (WT1) derived peptide, ... (7 entities in total)
• Functional Keywords: antibody, hla, mhc, rmf peptide, wt1, fab fragment 11d06, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 95365.74

Authors

Bujotzek, A.,Georges, G.,Hanisch, L.J.,Klein, C.,Benz, J. (deposition date: 2020-12-17, release date: 2021-10-27, Last modification date: 2022-01-05)

• Primary citation: Augsberger, C.,Hanel, G.,Xu, W.,Pulko, V.,Hanisch, L.J.,Augustin, A.,Challier, J.,Hunt, K.,Vick, B.,Rovatti, P.E.,Krupka, C.,Rothe, M.,Schonle, A.,Sam, J.,Lezan, E.,Ducret, A.,Ortiz-Franyuti, D.,Walz, A.C.,Benz, J.,Bujotzek, A.,Lichtenegger, F.S.,Gassner, C.,Carpy, A.,Lyamichev, V.,Patel, J.,Konstandin, N.,Tunger, A.,Schmitz, M.,von Bergwelt-Baildon, M.,Spiekermann, K.,Vago, L.,Jeremias, I.,Marrer-Berger, E.,Umana, P.,Klein, C.,Subklewe, M.; Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody.; Blood, 138:2655-2669, 2021; PubMed: 34280257; DOI: 10.1182/blood.2020010477

Experimental method

X-RAY DIFFRACTION (2.64 Å)