7AZN

Structure of mouse AsterC (GramD1c) with a new cholesterol-derived compound

Summary for 7AZN

• Entry DOI: 10.2210/pdb7azn/pdb
• Related: 6gqf
• Descriptor: Protein Aster-C, 20alpha-hydroxy-20-(5-methylhexyl)cholesterol, ETHANOL, ... (5 entities in total)
• Functional Keywords: non vesicular cholesterol transport, lipid-binding, endoplasmic reticulum, membrane contact sites, lipid transport
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 21618.87

Authors

Romartinez-Alonso, B.,Sirvydis, K.,Kim, Y.,Xiao, X.,Jung, M.,Tontonoz, P.,Schwabe, J. (deposition date: 2020-11-16, release date: 2021-01-13, Last modification date: 2024-01-31)

• Primary citation: Xiao, X.,Kim, Y.,Romartinez-Alonso, B.,Sirvydis, K.,Ory, D.S.,Schwabe, J.W.R.,Jung, M.E.,Tontonoz, P.; Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33376205; DOI: 10.1073/pnas.2024149118

Experimental method

X-RAY DIFFRACTION (2.09 Å)