7ASS
OXA-48_L67F_CAZ. What Doesnt Kill You Makes You Stronger: Sub-MIC Selection Drives Cryptic Evolution of OXA-48
Summary for 7ASS
Entry DOI | 10.2210/pdb7ass/pdb |
Descriptor | Beta-lactamase, CHLORIDE ION, hydrolyzed ceftazidime, ... (4 entities in total) |
Functional Keywords | oxa-48, ceftazidime, resistance development, cryptic evolution, escherichia coli, carbapenemase, carbapenem, collateral sensitivity, sub-mic, antibiotic |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 123203.42 |
Authors | Frohlich, C.,Leiros, H.-K.S. (deposition date: 2020-10-28, release date: 2020-12-16, Last modification date: 2024-01-31) |
Primary citation | Frohlich, C.,Gama, J.A.,Harms, K.,Hirvonen, V.H.A.,Lund, B.A.,van der Kamp, M.W.,Johnsen, P.J.,Samuelsen, O.,Leiros, H.S. Cryptic beta-Lactamase Evolution Is Driven by Low beta-Lactam Concentrations. Msphere, 6:-, 2021 Cited by PubMed: 33910990DOI: 10.1128/mSphere.00108-21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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