7ASS

OXA-48_L67F_CAZ. What Doesnt Kill You Makes You Stronger: Sub-MIC Selection Drives Cryptic Evolution of OXA-48

Summary for 7ASS

• Entry DOI: 10.2210/pdb7ass/pdb
• Descriptor: Beta-lactamase, CHLORIDE ION, hydrolyzed ceftazidime, ... (4 entities in total)
• Functional Keywords: oxa-48, ceftazidime, resistance development, cryptic evolution, escherichia coli, carbapenemase, carbapenem, collateral sensitivity, sub-mic, antibiotic
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 4
• Total formula weight: 123203.42

Authors

Frohlich, C.,Leiros, H.-K.S. (deposition date: 2020-10-28, release date: 2020-12-16, Last modification date: 2024-01-31)

• Primary citation: Frohlich, C.,Gama, J.A.,Harms, K.,Hirvonen, V.H.A.,Lund, B.A.,van der Kamp, M.W.,Johnsen, P.J.,Samuelsen, O.,Leiros, H.S.; Cryptic beta-Lactamase Evolution Is Driven by Low beta-Lactam Concentrations.; Msphere, 6:-, 2021; PubMed: 33910990; DOI: 10.1128/mSphere.00108-21

Experimental method

X-RAY DIFFRACTION (1.91 Å)