7AC8

Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.

Summary for 7AC8

Entry DOI	10.2210/pdb7ac8/pdb
Descriptor	Imidazole glycerol phosphate synthase subunit HisF, Imidazole glycerol phosphate synthase subunit HisH, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate, ... (6 entities in total)
Functional Keywords	enzyme regulation, allostery, ensemble model, conformational changes, hisf, hish, imidazole glycerol phosphate synthase, lyase (4.3.2.10), lyase
Biological source	Thermotoga maritima More
Total number of polymer chains	6
Total formula weight	154809.91
Authors	Sung, S.,Wilmanns, M. (deposition date: 2020-09-10, release date: 2021-05-19, Last modification date: 2024-01-31)
Primary citation	Wurm, J.P.,Sung, S.,Kneuttinger, A.C.,Hupfeld, E.,Sterner, R.,Wilmanns, M.,Sprangers, R. Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. Nat Commun, 12:2748-2748, 2021 Cited by PubMed: 33980881 DOI: 10.1038/s41467-021-22968-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation