7AC8

Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0016829	molecular_function	lyase activity
B	0000105	biological_process	L-histidine biosynthetic process
B	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
B	0004359	molecular_function	glutaminase activity
B	0005737	cellular_component	cytoplasm
B	0008652	biological_process	amino acid biosynthetic process
B	0009382	cellular_component	imidazoleglycerol-phosphate synthase complex
B	0016763	molecular_function	pentosyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
C	0000105	biological_process	L-histidine biosynthetic process
C	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
C	0005737	cellular_component	cytoplasm
C	0008652	biological_process	amino acid biosynthetic process
C	0016829	molecular_function	lyase activity
D	0000105	biological_process	L-histidine biosynthetic process
D	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
D	0004359	molecular_function	glutaminase activity
D	0005737	cellular_component	cytoplasm
D	0008652	biological_process	amino acid biosynthetic process
D	0009382	cellular_component	imidazoleglycerol-phosphate synthase complex
D	0016763	molecular_function	pentosyltransferase activity
D	0016787	molecular_function	hydrolase activity
D	0016829	molecular_function	lyase activity
E	0000105	biological_process	L-histidine biosynthetic process
E	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
E	0005737	cellular_component	cytoplasm
E	0008652	biological_process	amino acid biosynthetic process
E	0016829	molecular_function	lyase activity
F	0000105	biological_process	L-histidine biosynthetic process
F	0000107	molecular_function	imidazoleglycerol-phosphate synthase activity
F	0004359	molecular_function	glutaminase activity
F	0005737	cellular_component	cytoplasm
F	0008652	biological_process	amino acid biosynthetic process
F	0009382	cellular_component	imidazoleglycerol-phosphate synthase complex
F	0016763	molecular_function	pentosyltransferase activity
F	0016787	molecular_function	hydrolase activity
F	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue GUO A 301

Chain	Residue
A	LEU50
A	GLY177
A	SER201
A	GLY202
A	GLY203
A	LEU222
A	ALA223
A	ALA224
A	SER225
A	HOH404
A	HOH406
A	ILE52
A	HOH421
A	HOH425
A	HOH436
A	HOH443
B	MET-1
A	GLY82
A	ASN103
A	THR104
A	ASP130
A	SER144
A	THR171
A	ASP176

---

site_id	AC2
Number of Residues	10
Details	binding site for residue GLN B 301

Chain	Residue
A	GLN123
B	VAL51
B	GLY52
B	GLN88
B	GLU96
B	VAL140
B	HIS141
B	THR142
B	TYR143
B	HOH417

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 C 301

Chain	Residue
C	GLY82
C	ASN103
C	THR104
C	HOH434

---

site_id	AC4
Number of Residues	10
Details	binding site for residue GLN D 301

Chain	Residue
D	VAL51
D	GLY52
D	GLN88
D	GLU96
D	VAL140
D	HIS141
D	THR142
D	TYR143
D	HOH420
D	HOH470

---

site_id	AC5
Number of Residues	32
Details	binding site for residue GUO E 301

Chain	Residue
E	CYS9
E	ASP11
E	LYS19
E	PHE23
E	LEU50
E	ILE52
E	SER55
E	GLY81
E	GLY82
E	ASN103
E	THR104
E	ALA128
E	ASP130
E	SER144
E	ASP176
E	GLY177
E	SER201
E	GLY202
E	GLY203
E	LEU222
E	ALA223
E	ALA224
E	SER225
E	HOH407
E	HOH413
E	HOH414
E	HOH432
E	HOH438
E	HOH457
E	HOH458
E	HOH460
E	HOH476

---

site_id	AC6
Number of Residues	14
Details	binding site for residue GLN F 301

Chain	Residue
E	GLN123
F	GLY50
F	VAL51
F	GLY52
F	ALA84
F	LEU85
F	GLN88
F	GLU96
F	VAL140
F	HIS141
F	THR142
F	TYR143
F	HIS178
F	HOH426

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 753

Chain	Residue	Details
A	ASP11	proton acceptor, proton donor
A	ASP130	proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 753

Chain	Residue	Details
C	ASP11	proton acceptor, proton donor
C	ASP130	proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	2
Details	M-CSA 753

Chain	Residue	Details
E	ASP11	proton acceptor, proton donor
E	ASP130	proton acceptor, proton donor

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