7AC8
Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Imidazole glycerol phosphate synthase subunit HisF | polymer | 253 | 27753.9 | 3 | UniProt (Q9X0C6) Pfam (PF00977) | Thermotoga maritima | IGP synthase cyclase subunit,IGP synthase subunit HisF,ImGP synthase subunit HisF,IGPS subunit HisF |
| 2 | B, D, F (B, D, F) | Imidazole glycerol phosphate synthase subunit HisH | polymer | 203 | 23286.7 | 3 | UniProt (Q9X0C8) Pfam (PF00117) Pfam (PF07685) | Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) | IGP synthase glutaminase subunit,IGP synthase subunit HisH,ImGP synthase subunit HisH,IGPS subunit HisH,TmHisH |
| 3 | G, K (A, E) | [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | non-polymer | 577.3 | 2 | Chemie (GUO) | |||
| 4 | H, J, L (B, D, F) | GLUTAMINE | non-polymer | 146.1 | 3 | Chemie (GLN) | |||
| 5 | I (C) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
B, D, F: 1 - 201 (UniProt: Q9X0C8)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| Ala 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 153121.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1688.1 | |
| All* | Total formula weight | 154809.9 |
