7ABE

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-769

Summary for 7ABE

• Entry DOI: 10.2210/pdb7abe/pdb
• Related: 6QGP 6QGU 7A28 7A2F 7A8Q 7A9V 7AAG 7AB9 7ABD
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (9 entities in total)
• Functional Keywords: phosphodiesterase, hydrolase, camp hydrolysis, alternative splicing
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 173849.41

Authors

Singh, A.K.,Blaazer, A.R.,Zara, L.,de Esch, I.J.P.,Leurs, R.,Brown, D.G. (deposition date: 2020-09-07, release date: 2021-10-06, Last modification date: 2024-01-31)

• Primary citation: Singh, A.K.,Brown, D.G.; hPDE4D2 structure with inhibitor NPD-769; To be published,

Experimental method

X-RAY DIFFRACTION (1.83 Å)