7A28
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-617
Summary for 7A28
Entry DOI | 10.2210/pdb7a28/pdb |
Related | 6QGP 6QGU |
Descriptor | Phosphodiesterase, 1-cycloheptyl-3-(4-methoxy-3-{4-[4-(1H-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy}phenyl)-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one, ZINC ION, ... (8 entities in total) |
Functional Keywords | parasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 83791.82 |
Authors | Singh, A.K.,Blaazer, A.R.,Zara, L.,de Esch, I.J.P.,Leurs, R.,Brown, D.G. (deposition date: 2020-08-16, release date: 2021-08-25, Last modification date: 2024-01-31) |
Primary citation | Singh, A.K.,Brown, D.G. Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-617 To be published, |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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