7A59

Crimean-Congo Hemorrhagic Fever Virus Envelope Glycoprotein Gc W1191H/W1197A/W1199A Mutant in Postfusion Conformation (Orthorhombic Crystal Form)

Summary for 7A59

• Entry DOI: 10.2210/pdb7a59/pdb
• Descriptor: Envelopment polyprotein, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: virus entry, class ii membrane fusion protein, viral protein
• Biological source: Crimean-Congo hemorrhagic fever virus strain IbAr10200 (CCHFV)
• Total number of polymer chains: 3
• Total formula weight: 181257.32

Authors

Hellert, J.,Guardado-Calvo, P.,Rey, F.A. (deposition date: 2020-08-20, release date: 2021-10-06, Last modification date: 2022-04-20)

• Primary citation: Mishra, A.K.,Hellert, J.,Freitas, N.,Guardado-Calvo, P.,Haouz, A.,Fels, J.M.,Maurer, D.P.,Abelson, D.M.,Bornholdt, Z.A.,Walker, L.M.,Chandran, K.,Cosset, F.L.,McLellan, J.S.,Rey, F.A.; Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.; Science, 375:104-109, 2022; PubMed: 34793197; DOI: 10.1126/science.abl6502

Experimental method

X-RAY DIFFRACTION (2.197 Å)