7A59

Crimean-Congo Hemorrhagic Fever Virus Envelope Glycoprotein Gc W1191H/W1197A/W1199A Mutant in Postfusion Conformation (Orthorhombic Crystal Form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Envelopment polyprotein	polymer	538	59870.8	3	UniProt (Q8JSZ3) Pfam (PF01561) Pfam (PF20682) In PDB	Crimean-Congo hemorrhagic fever virus strain IbAr10200 (CCHFV)	M polyprotein
2	D	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		894.8	1	In PDB GlyTouCan (G00395TQ)
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	A, B, C	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
5	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6		water	water		18.0	729	Chemie (HOH)

Sequence modifications

A, B, C: 1041 - 1561 (UniProt: Q8JSZ3)

PDB	External Database	Details
His 1191	Trp 1191	engineered mutation
Ala 1197	Trp 1197	engineered mutation
Ala 1199	Trp 1199	engineered mutation
Glu 1562	-	expression tag
Asn 1563	-	expression tag
Leu 1564	-	expression tag
Tyr 1565	-	expression tag
Phe 1566	-	expression tag
Gln 1567	-	expression tag
Ser 1568	-	expression tag
Ala 1569	-	expression tag
Gly 1570	-	expression tag
Trp 1571	-	expression tag
Ser 1572	-	expression tag
His 1573	-	expression tag
Pro 1574	-	expression tag
Gln 1575	-	expression tag
Phe 1576	-	expression tag
Glu 1577	-	expression tag
Lys 1578	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	179612.4
Branched	Number of molecules	1
	Total formula weight	894.8
Non-Polymers*	Number of molecules	9
	Total formula weight	750.1
All*	Total formula weight	181257.3

*Water molecules are not included.