7A4K

tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with tetramethylene sulfoxide

Summary for 7A4K

• Entry DOI: 10.2210/pdb7a4k/pdb
• Related: 7A0B
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: enzyme, disulfide, fragment, transferase
• Biological source: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• Total number of polymer chains: 1
• Total formula weight: 43356.47

Authors

Nguyen, D.,Heine, A.,Klebe, G. (deposition date: 2020-08-19, release date: 2021-06-16, Last modification date: 2024-01-31)

• Primary citation: Nguyen, D.,Xie, X.,Jakobi, S.,Terwesten, F.,Metz, A.,Nguyen, T.X.P.,Palchykov, V.A.,Heine, A.,Reuter, K.,Klebe, G.; Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.; Acs Chem.Biol., 16:1090-1098, 2021; PubMed: 34081441; DOI: 10.1021/acschembio.1c00296

Experimental method

X-RAY DIFFRACTION (1.68 Å)