7ZMZ
Engineered Interleukin 2 bound to CD25 receptor
Summary for 7ZMZ
Entry DOI | 10.2210/pdb7zmz/pdb |
Descriptor | Interleukin-2, Interleukin-2 receptor subunit alpha (2 entities in total) |
Functional Keywords | cytokine receptor, protein engineering, signaling protein, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 45837.69 |
Authors | Fyfe, P.K.,Moraga, I.,Gaggero, S.,Mitra, S. (deposition date: 2022-04-20, release date: 2022-12-14, Last modification date: 2024-01-31) |
Primary citation | Gaggero, S.,Martinez-Fabregas, J.,Cozzani, A.,Fyfe, P.K.,Leprohon, M.,Yang, J.,Thomasen, F.E.,Winkelmann, H.,Magnez, R.,Conti, A.G.,Wilmes, S.,Pohler, E.,van Gijsel Bonnello, M.,Thuru, X.,Quesnel, B.,Soncin, F.,Piehler, J.,Lindorff-Larsen, K.,Roychoudhuri, R.,Moraga, I.,Mitra, S. IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Sci Immunol, 7:eade5686-eade5686, 2022 Cited by PubMed: 36459543DOI: 10.1126/sciimmunol.ade5686 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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