7WJV
Crystal structure of human liver FBPase complexed with an covalent inhibitor
Summary for 7WJV
Entry DOI | 10.2210/pdb7wjv/pdb |
Descriptor | Fructose-1,6-bisphosphatase 1, ADENOSINE MONOPHOSPHATE, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ... (7 entities in total) |
Functional Keywords | classification: hydrolase organism(s): homo sapiens expression system: escherichia coli bl21(de3) inhibitor: covalent binding c128, cytosolic protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 154875.51 |
Authors | |
Primary citation | Wen, W.,Cao, H.,Xu, Y.,Ren, Y.,Rao, L.,Shao, X.,Chen, H.,Wu, L.,Liu, J.,Su, C.,Peng, C.,Huang, Y.,Wan, J. N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction. J.Med.Chem., 65:9126-9143, 2022 Cited by PubMed: 35786925DOI: 10.1021/acs.jmedchem.2c00336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.724 Å) |
Structure validation
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