7UY3
Crystal structure of human Fgr tyrosine kinase in complex with TL02-59
Summary for 7UY3
Entry DOI | 10.2210/pdb7uy3/pdb |
Descriptor | Tyrosine-protein kinase Fgr, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | fgr, tl02-59, signaling protein, kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 53195.00 |
Authors | Du, S.,Alvarado, J.J.,Smithgall, T.E. (deposition date: 2022-05-06, release date: 2022-12-28, Last modification date: 2023-11-15) |
Primary citation | Du, S.,Alvarado, J.J.,Wales, T.E.,Moroco, J.A.,Engen, J.R.,Smithgall, T.E. ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30:1508-1517.e3, 2022 Cited by PubMed: 36115344DOI: 10.1016/j.str.2022.08.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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