7UJV
Structure of PHD2 in complex with HIF2a-CODD
Summary for 7UJV
Entry DOI | 10.2210/pdb7ujv/pdb |
Descriptor | Egl nine homolog 1, Endothelial PAS domain-containing protein 1, N-OXALYLGLYCINE, ... (6 entities in total) |
Functional Keywords | hif-prolyl-hydroxylase, complex, oxygen-sensing, psuedohypoxic-disease, oxidoreductase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 30416.15 |
Authors | Ferens, F.G.,Tarade, D.,Lee, J.E.,Ohh, M. (deposition date: 2022-03-31, release date: 2023-04-05, Last modification date: 2024-03-13) |
Primary citation | Ferens, F.G.,Taber, C.C.,Stuart, S.,Hubert, M.,Tarade, D.,Lee, J.E.,Ohh, M. Deficiency in PHD2-mediated hydroxylation of HIF2 alpha underlies Pacak-Zhuang syndrome. Commun Biol, 7:240-240, 2024 Cited by PubMed: 38418569DOI: 10.1038/s42003-024-05904-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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