7T9M
Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist
Summary for 7T9M
Entry DOI | 10.2210/pdb7t9m/pdb |
EMDB information | 25762 |
Descriptor | CS-17 Heavy Chain, CS-17 Light Chain, Thyrotropin receptor, ... (5 entities in total) |
Functional Keywords | g protein-coupled receptor, thyroid-stimulating hormone receptor, thyrotropin receptor, cs-17 fab, thyroid, membrane protein |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 127392.03 |
Authors | Faust, B.,Cheng, Y.,Manglik, A. (deposition date: 2021-12-19, release date: 2022-08-10, Last modification date: 2022-10-05) |
Primary citation | Faust, B.,Billesbolle, C.B.,Suomivuori, C.M.,Singh, I.,Zhang, K.,Hoppe, N.,Pinto, A.F.M.,Diedrich, J.K.,Muftuoglu, Y.,Szkudlinski, M.W.,Saghatelian, A.,Dror, R.O.,Cheng, Y.,Manglik, A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609:846-853, 2022 Cited by PubMed: 35940205DOI: 10.1038/s41586-022-05159-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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