7ST5

Structure of Fab CC-95251 in complex with SIRP-alpha

Summary for 7ST5

Entry DOI	10.2210/pdb7st5/pdb
Descriptor	Fab CC-95251 anti-SIRP-alpha heavy chain, Fab CC-95251 anti-SIRP-alpha light chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (6 entities in total)
Functional Keywords	cell surface receptor, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	122338.78
Authors	Fenalti, G. (deposition date: 2021-11-12, release date: 2023-05-17, Last modification date: 2024-05-29)
Primary citation	Chan, H.,Trout, C.V.,Mikolon, D.,Adams, P.,Guzman, R.,Mavrommatis, K.,Abbasian, M.,Hadjivassiliou, H.,Dearth, L.,Fox, B.A.,Sivakumar, P.,Cho, H.,Hariharan, K. Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRP alpha That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies. Cancer Res Commun, 4:505-515, 2024 Cited by PubMed: 38319147 DOI: 10.1158/2767-9764.CRC-23-0634 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation