7SQL
Crystal structure of human uridine-cytidine kinase 2 complexed with a weak small molecule inhibitor
Summary for 7SQL
Entry DOI | 10.2210/pdb7sql/pdb |
Descriptor | Uridine-cytidine kinase 2, TRIETHYLENE GLYCOL, GLYCEROL, ... (7 entities in total) |
Functional Keywords | kinase, uridine kinase, cytidine kinase, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 114759.47 |
Authors | Mashayekh, S.,Stunkard, L.M.,Kienle, M.,Mathews, I.I.,Khosla, C. (deposition date: 2021-11-05, release date: 2022-10-12, Last modification date: 2023-10-25) |
Primary citation | Mashayekh, S.,Stunkard, L.M.,Kienle, M.,Mathews, I.I.,Khosla, C. Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2). Biochemistry, 61:2261-2266, 2022 Cited by PubMed: 36190114DOI: 10.1021/acs.biochem.2c00451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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