7RY8
S. CEREVISIAE CYP51 Y140H mutant COMPLEXED WITH Voriconazole
Summary for 7RY8
Entry DOI | 10.2210/pdb7ry8/pdb |
Related | 4ZE3 5HS1 |
Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole, ... (6 entities in total) |
Functional Keywords | cyp51, oxidoreductase-oxidoreductase inhibitor complex, sterol biosynthesis, oxidoreductase, oxidoreductase/oxidoreductase inhibitor |
Biological source | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
Total number of polymer chains | 1 |
Total formula weight | 63244.42 |
Authors | Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.,Monk, B.C. (deposition date: 2021-08-24, release date: 2021-09-01, Last modification date: 2023-10-18) |
Primary citation | Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C. Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase as a Surrogate. J Fungi (Basel), 7:-, 2021 Cited by PubMed: 34829185DOI: 10.3390/jof7110897 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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