7RY8
S. CEREVISIAE CYP51 Y140H mutant COMPLEXED WITH Voriconazole
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0008398 | molecular_function | sterol 14-demethylase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG |
| Chain | Residue | Details |
| A | PHE463-GLY472 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:16847258, ECO:0000269|PubMed:24613931 |
| Chain | Residue | Details |
| A | MET1-SER20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:16847258, ECO:0000269|PubMed:24613931 |
| Chain | Residue | Details |
| A | HIS21-TYR41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 488 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:16847258, ECO:0000269|PubMed:24613931 |
| Chain | Residue | Details |
| A | ASN42-ILE530 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24613931, ECO:0007744|PDB:4LXJ |
| Chain | Residue | Details |
| A | TYR126 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24613931, ECO:0007744|PDB:5EQB |
| Chain | Residue | Details |
| A | GLY314 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:24613931, ECO:0007744|PDB:4LXJ, ECO:0007744|PDB:5EQB |
| Chain | Residue | Details |
| A | CYS470 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950 |
| Chain | Residue | Details |
| A | SER458 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS116 | |
| A | LYS353 | |
| A | LYS454 |
