7Q1D

Acetyltrasferase(3) type IIIa in complex with 3-N-methyl-nemycin B

Summary for 7Q1D

• Entry DOI: 10.2210/pdb7q1d/pdb
• Related: 7q0q 7q10
• Descriptor: Aminoglycoside N(3)-acetyltransferase III, SODIUM ION, [[(2~{R},3~{S})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[(3~{S})-3-[2-[(1~{S})-1-[[(1~{S},2~{R},3~{R},4~{S},5~{R})-5-azanyl-3-[(4~{S},5~{R})-4-[(2~{S},3~{R},4~{R},5~{S},6~{E})-3-azanyl-6-(azanylmethylidene)-4,5-bis(oxidanyl)oxan-2-yl]oxy-5-(hydroxymethyl)-3-oxidanyl-oxolan-2-yl]oxy-2-[(2~{S},3~{R},4~{R},5~{S})-3-azanyl-6-(iminomethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-4-oxidanyl-cyclohexyl]amino]-1-oxidanyl-ethyl]sulfanylethylamino]-3-oxidanyl-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate, ... (7 entities in total)
• Functional Keywords: acetyltrasferase, aminoglycosides, inhibitor, complex, antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 4
• Total formula weight: 132205.30

Authors

Pontillo, N.,Guskov, A. (deposition date: 2021-10-18, release date: 2022-11-02, Last modification date: 2024-01-31)

• Primary citation: Pontillo, N.,Warszawik, E.M.,Partipilo, M.,Stetsenko, A.,Loznik, M.,Yang, X.,Slotboom, D.J.,Guskov, A.,Herrmann, A.; 3-N-alkylation in aminoglycoside antibiotic neomycin B overcomes bacterial resistance mediated by acetyltransferase (3) IIIa; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.43 Å)