7LM8
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with two cross-neutralizing antibodies CV38-142 and COVA1-16 Fabs isolated from COVID-19 patients
Summary for 7LM8
Entry DOI | 10.2210/pdb7lm8/pdb |
Descriptor | Spike protein S1, COVA1-16 Fab heavy chain, COVA1-16 Fab light chain, ... (8 entities in total) |
Functional Keywords | sars-cov-2, sars-cov, antibody, spike, coronavirus, covid-19, sars, immune system, viral protein-immune system complex, cross-neutralization, synergy, viral protein, viral protein/immune system |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 5 |
Total formula weight | 124237.32 |
Authors | Liu, H.,Wilson, I.A. (deposition date: 2021-02-05, release date: 2021-03-31, Last modification date: 2023-10-18) |
Primary citation | Liu, H.,Yuan, M.,Huang, D.,Bangaru, S.,Zhao, F.,Lee, C.D.,Peng, L.,Barman, S.,Zhu, X.,Nemazee, D.,Burton, D.R.,van Gils, M.J.,Sanders, R.W.,Kornau, H.C.,Reincke, S.M.,Pruss, H.,Kreye, J.,Wu, N.C.,Ward, A.B.,Wilson, I.A. A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. Cell Host Microbe, 29:806-818.e6, 2021 Cited by PubMed: 33894127DOI: 10.1016/j.chom.2021.04.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.936 Å) |
Structure validation
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