7KP7
asymmetric mTNF-alpha hTNFR1 complex
Summary for 7KP7
Entry DOI | 10.2210/pdb7kp7/pdb |
Descriptor | Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A, SULFATE ION, ... (5 entities in total) |
Functional Keywords | tumour necrosis factor alpha, tnf, receptor, tnfr1, asymmetric, protein-protein inhibitor, cytokine |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 101811.19 |
Authors | Arakaki, T.L.,Fox III, D.,Edwards, T.E.,Foley, A.,Ceska, T. (deposition date: 2020-11-10, release date: 2021-01-13, Last modification date: 2024-04-03) |
Primary citation | McMillan, D.,Martinez-Fleites, C.,Porter, J.,Fox 3rd, D.,Davis, R.,Mori, P.,Ceska, T.,Carrington, B.,Lawson, A.,Bourne, T.,O'Connell, J. Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12:582-582, 2021 Cited by PubMed: 33495441DOI: 10.1038/s41467-020-20828-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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