7K48
Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV
Summary for 7K48
Entry DOI | 10.2210/pdb7k48/pdb |
EMDB information | 22661 |
Descriptor | Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a (2 entities in total) |
Functional Keywords | ion channel, voltage-gated sodium channel, gating-modifier toxin, membrane protein |
Biological source | Escherichia coli (strain K12) More |
Total number of polymer chains | 8 |
Total formula weight | 290075.36 |
Authors | Wisedchaisri, G.,Tonggu, L.,Gamal El-Din, T.M.,McCord, E.,Zheng, N.,Catterall, W.A. (deposition date: 2020-09-15, release date: 2020-12-02, Last modification date: 2021-01-20) |
Primary citation | Wisedchaisri, G.,Tonggu, L.,Gamal El-Din, T.M.,McCord, E.,Zheng, N.,Catterall, W.A. Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin. Mol.Cell, 81:38-48.e4, 2021 Cited by PubMed: 33232657DOI: 10.1016/j.molcel.2020.10.039 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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