7FB7
Crystal structure of human UHRF1 TTD in complex with 5-amino-2,4-dimethylpyridine
Summary for 7FB7
Entry DOI | 10.2210/pdb7fb7/pdb |
Descriptor | E3 ubiquitin-protein ligase UHRF1, (4S)-2-METHYL-2,4-PENTANEDIOL, 5-amino-2,4-dimethylpyridine, ... (6 entities in total) |
Functional Keywords | dna methylation, histone modification, inhibitor, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 37546.07 |
Authors | Kori, S.,Arita, K.,Yoshimi, S. (deposition date: 2021-07-08, release date: 2022-01-05, Last modification date: 2023-11-29) |
Primary citation | Kori, S.,Shibahashi, Y.,Ekimoto, T.,Nishiyama, A.,Yoshimi, S.,Yamaguchi, K.,Nagatoishi, S.,Ohta, M.,Tsumoto, K.,Nakanishi, M.,Defossez, P.A.,Ikeguchi, M.,Arita, K. Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. Bioorg.Med.Chem., 52:116500-116500, 2021 Cited by PubMed: 34801826DOI: 10.1016/j.bmc.2021.116500 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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