7EOW
High-resolution structure of vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine
Summary for 7EOW
Entry DOI | 10.2210/pdb7eow/pdb |
Descriptor | von Willebrand factor, caplacizumab (3 entities in total) |
Functional Keywords | vwf, vfw a1, caplacizumab, nanobody, structural protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 41567.22 |
Authors | Lee, H.T.,Heo, Y.-S. (deposition date: 2021-04-23, release date: 2021-07-07, Last modification date: 2023-11-29) |
Primary citation | Lee, H.T.,Park, U.B.,Jeong, T.J.,Gu, N.,Lee, S.H.,Kim, Y.,Heo, Y.S. High-resolution structure of the vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine for treating acquired TTP. Biochem.Biophys.Res.Commun., 567:49-55, 2021 Cited by PubMed: 34144500DOI: 10.1016/j.bbrc.2021.06.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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