7ENQ
Crystal structure of human NAMPT in complex with compound NAT
Summary for 7ENQ
Entry DOI | 10.2210/pdb7enq/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | nampt, nat, nad, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 227462.52 |
Authors | |
Primary citation | Yao, H.,Liu, M.,Wang, L.,Zu, Y.,Wu, C.,Li, C.,Zhang, R.,Lu, H.,Li, F.,Xi, S.,Chen, S.,Gu, X.,Liu, T.,Cai, J.,Wang, S.,Yang, M.,Xing, G.G.,Xiong, W.,Hua, L.,Tang, Y.,Wang, G. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res., 32:570-584, 2022 Cited by PubMed: 35459935DOI: 10.1038/s41422-022-00651-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.20496616708 Å) |
Structure validation
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