7EDZ
Crystal Structure of human PPCS in complex with P-HoPan and AMPPNP
Summary for 7EDZ
Entry DOI | 10.2210/pdb7edz/pdb |
Descriptor | Phosphopantothenate--cysteine ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... (7 entities in total) |
Functional Keywords | phosphopantothenoylcysteine synthetase, ligase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 140840.25 |
Authors | Sharma, N.,Mostert, K.J.,Strauss, E.,Anand, R. (deposition date: 2021-03-17, release date: 2021-11-24, Last modification date: 2023-11-29) |
Primary citation | Mostert, K.J.,Sharma, N.,van der Zwaag, M.,Staats, R.,Koekemoer, L.,Anand, R.,Sibon, O.C.M.,Strauss, E. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. Acs Chem.Biol., 16:2401-2414, 2021 Cited by PubMed: 34582681DOI: 10.1021/acschembio.1c00535 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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