7CMM
Crystal structure of TEAD1-YBD in complex with K-975
Summary for 7CMM
Entry DOI | 10.2210/pdb7cmm/pdb |
Descriptor | Transcriptional enhancer factor TEF-1, N-[3-(4-chloranylphenoxy)-4-methyl-phenyl]propanamide (3 entities in total) |
Functional Keywords | transcriptional enhancer factor tef-1, tead, tead1, yap binding domain, ybd, inhibitor, covalent binder, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 107439.68 |
Authors | Tsuji, Y.,Suzuki, M.,Yasunaga, M.,Hamguchi, K.,Saito, J. (deposition date: 2020-07-28, release date: 2021-02-03, Last modification date: 2023-11-29) |
Primary citation | Kaneda, A.,Seike, T.,Danjo, T.,Nakajima, T.,Otsubo, N.,Yamaguchi, D.,Tsuji, Y.,Hamaguchi, K.,Yasunaga, M.,Nishiya, Y.,Suzuki, M.,Saito, J.I.,Yatsunami, R.,Nakamura, S.,Sekido, Y.,Mori, K. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res, 10:4399-4415, 2020 Cited by PubMed: 33415007PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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