7B12
HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid
Summary for 7B12
Entry DOI | 10.2210/pdb7b12/pdb |
Descriptor | Proteasome subunit beta type-1, Proteasome subunit beta type-9, Proteasome subunit beta type-3, ... (18 entities in total) |
Functional Keywords | multicatalytic proteinase, 20s proteasome, protease, hydrolase, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 28 |
Total formula weight | 694451.39 |
Authors | Musil, D.,Klein, M.,Crosignani, S. (deposition date: 2020-11-23, release date: 2021-12-01, Last modification date: 2023-06-14) |
Primary citation | Klein, M.,Busch, M.,Friese-Hamim, M.,Crosignani, S.,Fuchss, T.,Musil, D.,Rohdich, F.,Sanderson, M.P.,Seenisamy, J.,Walter-Bausch, G.,Zanelli, U.,Hewitt, P.,Esdar, C.,Schadt, O. Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i). J.Med.Chem., 64:10230-10245, 2021 Cited by PubMed: 34228444DOI: 10.1021/acs.jmedchem.1c00604 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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