7B05
TRPC4 in complex with inhibitor GFB-8749
Summary for 7B05
Entry DOI | 10.2210/pdb7b05/pdb |
EMDB information | 11957 4339 |
Descriptor | Transient receptor potential cation channel subfamily c member 4a, 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{H}-pyridazin-6-one, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | ion channel, trpc4, inhibitor, complex, membrane protein, transport protein |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 4 |
Total formula weight | 423895.46 |
Authors | Vinayagam, D.,Quentin, D.,Sistel, O.,Merino, F.,Stabrin, M.,Hofnagel, O.,Ledeboer, M.W.,Malojcic, G.,Raunser, S. (deposition date: 2020-11-18, release date: 2020-12-09, Last modification date: 2024-05-01) |
Primary citation | Vinayagam, D.,Quentin, D.,Yu-Strzelczyk, J.,Sitsel, O.,Merino, F.,Stabrin, M.,Hofnagel, O.,Yu, M.,Ledeboer, M.W.,Nagel, G.,Malojcic, G.,Raunser, S. Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9:-, 2020 Cited by PubMed: 33236980DOI: 10.7554/eLife.60603 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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