7AML
RET/GDNF/GFRa1 extracellular complex Cryo-EM structure
Summary for 7AML
Entry DOI | 10.2210/pdb7aml/pdb |
Related | 7AB8 7AMK |
EMDB information | 11822 |
Descriptor | Proto-oncogene tyrosine-protein kinase receptor Ret, GDNF family receptor alpha, Glial cell line-derived neurotrophic factor, ... (5 entities in total) |
Functional Keywords | vertebrate development, part of the ret-gfl-gfra complex, neurotrophic factor, signaling protein |
Biological source | Danio rerio (Zebrafish) More |
Total number of polymer chains | 6 |
Total formula weight | 245538.29 |
Authors | Adams, S.E.,Earl, C.P.,Purkiss, A.G.,McDonald, N.Q. (deposition date: 2020-10-09, release date: 2021-01-13, Last modification date: 2021-07-14) |
Primary citation | Adams, S.E.,Purkiss, A.G.,Knowles, P.P.,Nans, A.,Briggs, D.C.,Borg, A.,Earl, C.P.,Goodman, K.M.,Nawrotek, A.,Borg, A.J.,McIntosh, P.B.,Houghton, F.M.,Kjaer, S.,McDonald, N.Q. A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29:694-, 2021 Cited by PubMed: 33484636DOI: 10.1016/j.str.2020.12.012 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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