7AAZ
Crystal structure of MerTK in complex with a type 1.5 aminopyridine inhibitor
Summary for 7AAZ
Entry DOI | 10.2210/pdb7aaz/pdb |
Related | 7AAX 7AAY |
Descriptor | Tyrosine-protein kinase Mer, 2-azanyl-~{N}-[(1~{S},2~{S})-2-[[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1-methylpyrazol-4-yl)pyridine-3-carboxamide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | tyrosine kinase inhibitor, structure-based drug design, type 1.5 inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34916.95 |
Authors | Pflug, A.,Schimpl, M.,McCoull, W.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J. (deposition date: 2020-09-05, release date: 2020-11-04, Last modification date: 2024-01-31) |
Primary citation | Pflug, A.,Schimpl, M.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,McCoull, W. A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477:4443-4452, 2020 Cited by PubMed: 33119085DOI: 10.1042/BCJ20200735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.855 Å) |
Structure validation
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